diabetic kidney disease

Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide

Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compounds, such as …

Processed foods drive intestinal barrier permeability and microvascular diseases

Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet …

Targeted deletion of NADPH-Oxidase Nox4 from proximal tubules is dispensable for diabetic kidney disease development

Background The nicotinamide adenine dinucleotide phosphate oxidase isoform 4 (Nox4) mediates reactive oxygen species (ROS) production and renal fibrosis in diabetic kidney disease (DKD) at the level of the podocyte. However, the mitochondrial …

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy

Alterations in gut homeostasis may contribute to the progression of diabetic nephropathy. There has been recent attention on the renoprotective effects of metabolite-sensing receptors in chronic renal injury, including the G protein-coupled receptor …

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Mitochondrial stress has been widely observed in diabetic kidney disease (DKD). Cyclophilin D (CypD) is a functional component of the mitochondrial permeability transition pore (mPTP) which allows the exchange of ions and solutes between the …

The Devil's in the Detail: The Importance of Specific, Descriptive Language for Reproducibility in Nutrition Science

Full Citation Matthew Snelson, Melinda T Coughlan, The Devil’s in the Detail: The Importance of Specific, Descriptive Language for Reproducibility in Nutrition Science, Journal of Renal Nutrition, Volume XX, Issue X, XXX 2019, Pages XXX-XXX [Article In Press]

Advanced Glycation Endproduct-Induced Albuminuria and Changes in Gut Microbiota and Metabolome are Attenuated by Resistant Starch in a Mouse Model of Type 2 Diabetes

Australasian Diabetes Congress 2019

Resistant starch supplementation is not associated with protection against diabetic nephropathy in the STZ-induced diabetic mouse model

Australasian Diabetes Congress 2019

Resistant starch is protective against diabetic nephropathy by inhibition of complement activation in a mouse model of diabetes

Nutrition Society of Australia 43rd Annual Scientific Meeting

Dietary Resistant Starch Protects Against Diabetic Nephropathy by Inhibition of Complement

54th Australian and New Zealand Society of Nephrology Annual Scientific Meeting