diabetes

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes

There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such …

The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease

The metabolic disorder, diabetes mellitus, results in microvascular complications, including diabetic kidney disease (DKD), which is partly believe to involve disrupted energy generation in the kidney, leading to injury that is characterized by …

Microbial influencers: treating diabetes through the gut

A recently published study by Bell et al. shows altered immunotolerance in people with type 1 diabetes by dietary supplementation of modified resistant starch fibre.

The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes

There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous …

Gut microbiome, prebiotics, intestinal permeability and diabetes complications

Diabetes is a metabolic condition. The composition of the gut microbiota is altered in diabetes with reduced levels of short chain fatty acids (SCFA) producers, notably butyrate. Butyrate is associated with a number of beneficial effects including …

Complement C5a Induces Renal Injury in Diabetic Kidney Disease Via Disruption in Mitochondrial Metabolic Agility

The sequelae of diabetes mellitus include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury that is associated with a disruption in mitochondrial metabolic agility, inflammation and …

Diabetes and the gut microbiota: sorting through the crap

Australasian Diabetes Congress 2019

Metabolic effects of resistant starch type 2: a systematic literature review and meta-analysis of randomised controlled trials

Published evidence exploring the effects of dietary resistant starch (RS) on human cardiometabolic health is inconsistent. This review aimed to investigate the effect of dietary RS type 2 (RS2) supplementation on body weight, satiety ratings, fasting …

Metabolic effects of resistant starch type 2: a systematic literature review and meta-analysis of randomised controlled trials

Nutrition Society of Australia 43rd Annual Scientific Meeting