Metabolic effects of resistant starch type 2: a systematic literature review and meta-analysis of randomised controlled trials

Canberra, Australia


Published evidence exploring effects of dietary resistant starch (RS) on cardiometabolic health is inconsistent. This review aimed to investigate the effect of dietary RS type 2 (RS2) supplementation on body weight, satiety ratings, fasting plasma glucose, HbA1c, insulin resistance and lipid levels in healthy individuals and those with overweight/obesity, the metabolic syndrome (MetS) or type 2 diabetes mellitus (T2DM). Five electronic databases were searched for Randomised Controlled Trials (RCTs) published in English between 1982-2017, investigating the effect of dietary RS2 supplementation on cardiometabolic health. Trials were eligible for inclusion if they reported RCTs involving humans where at least one group received ≥10 grams of RS2 per day for ≥1 week, and measured body weight, satiety, glucose and/or lipid metabolic outcomes. Twenty RCTs involving 569 participants were included. RS2 supplementation significantly reduced serum triacylglycerol concentrations (Mean difference= -0.11 mmol/L; 95% CI -0.18, -0.04, P=0.002) in healthy individuals (n=227) and reduced body weight (MD= -1.29kg; 95% CI -2.40, -0.17, P=0.02) in people with T2DM (n=90), but had no effect on appetite, fasting plasma glucose, HbA1c, HOMA-IR, total cholesterol, LDL-cholesterol or HDL-cholesterol in any patient sub-groups. Most studies had a moderate-high risk of bias, were of short duration and contained small sample sizes. High quality, long-term trials are required to determine the efficacy of RS2 supplementation as a dietary strategy in the management of metabolic disease.

Matthew Snelson
Research Fellow, Department of Diabetes

My research interests include diet-microbiota interactions, diabetic kidney disease and prebiotics