Resistant Starch

Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment

Background: Dietary-resistant starch is emerging as a potential therapeutic tool to limit the negative effects of diabetes on the kidneys. However, its metabolic and immunomodulatory effects have not yet been fully elucidated. Methods: Six-week-old …

Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a …

Microbial influencers: treating diabetes through the gut

A recently published study by Bell et al. shows altered immunotolerance in people with type 1 diabetes by dietary supplementation of modified resistant starch fibre.

Gut microbiome, prebiotics, intestinal permeability and diabetes complications

Diabetes is a metabolic condition. The composition of the gut microbiota is altered in diabetes with reduced levels of short chain fatty acids (SCFA) producers, notably butyrate. Butyrate is associated with a number of beneficial effects including …

Deficiency of Prebiotic Fibre and Insufficient Signalling Through Gut Metabolite Sensing Receptors Leads to Cardiovascular Disease

Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Amongst key Western lifestyle factors, a diet poor in fibre is associated with prevalence of high BP. The impact of …

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy

Alterations in gut homeostasis may contribute to the progression of diabetic nephropathy. There has been recent attention on the renoprotective effects of metabolite-sensing receptors in chronic renal injury, including the G protein-coupled receptor …

The Devil's in the Detail: The Importance of Specific, Descriptive Language for Reproducibility in Nutrition Science

Full Citation Matthew Snelson, Melinda T Coughlan, The Devil’s in the Detail: The Importance of Specific, Descriptive Language for Reproducibility in Nutrition Science, Journal of Renal Nutrition, Volume XX, Issue X, XXX 2019, Pages XXX-XXX [Article In Press]

Advanced Glycation Endproduct-Induced Albuminuria and Changes in Gut Microbiota and Metabolome are Attenuated by Resistant Starch in a Mouse Model of Type 2 Diabetes

Australasian Diabetes Congress 2019

Resistant starch supplementation is not associated with protection against diabetic nephropathy in the STZ-induced diabetic mouse model

Australasian Diabetes Congress 2019

Metabolic effects of resistant starch type 2: a systematic literature review and meta-analysis of randomised controlled trials

Published evidence exploring the effects of dietary resistant starch (RS) on human cardiometabolic health is inconsistent. This review aimed to investigate the effect of dietary RS type 2 (RS2) supplementation on body weight, satiety ratings, fasting …